Levitra Erectile Dysfunction Therapy More specifically, penile erection is a haemodynamic process. During sexual stimulation, nitric oxide is subsequently released. The nitric acid activates an enzyme guanylate cyclase, resulting in an increased level of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum of the penis. This results in smooth muscle relaxation in the penis, allowing increased inflow of blood into the penis. The level of cGMP is regulated by the rate of synthesis via guanylate cyclase and by the rate of degradation via cGMP hydrolysing phosphodiesterases (PDEs). |