Uprima Online Information
Most men suffer from erectile dysfunction at some point in their lives perhaps as a result of illness, stress, complications with their relationship, etc. Erectile dysfunction is defined as the inability to achieve or maintain an erection sufficient for sexual intercourse. Erectile dysfunction affects some 152 million men and their partners worldwide. Fortunately, there is now help for men with erectile dysfunction. Uprima acts as a dopamine receptor agonist that works in the brain to improve erectile function by enhancing the natural process or signal to the penis following sexual stimulation.
"Uprima offers several benefits for patients with erectile dysfunction: Uprima works fast, and Uprima works similarly to the way men normally have erections," said Professor Jeremy Heaton, of Queen's University and Kingston General Hospital, Ontario, Canada. "Long-term data in men who continued in studies demonstrate that Uprima is successful in more than 90 percent of attempts at intercourse."
Additional Uprima Online Information
The following Uprima topics represent the most commonly asked questions concerning the use of Uprima for the treatment of erectile dysfunction. The following Uprima information has been compiled from a variety of resources in order to give the reader an overview of the use and various effects of Uprima in treating erectile dysfunction.
What is Uprima?
Uprima (apomorphine) is one of the most recent impotence medications on the market designed to help men achieve and maintain a sufficient erection for intercourse.
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Why is Uprima sometimes called apomorphine hcl?
Apomorphine is the generic name for Uprima. The generic name represents the medications nonproprietary or chemical name, whereas, the brand name is the name a pharmaceutical give to a medication for marketing purposes.
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What is the mechanism of action of Uprima?
Uprima is the first clinically tested sublingual medication to enhance erections by activating chemicals found in the brain. Uprima tablets are dissolved under the tongue which stimulate dopamine receptors in the hypothalamus and mid brain regions. Subsequently, once sexual stimulation as occurred an excitatory signal is transmitted via the spinal cord to stimulate parasympathetic activity in the pelvic region that results in smooth muscle relaxation in the walls of the arteries supplying the penis. The relaxation of walls of these arteries allows the arteries to expand so more blood can flow to the region, hence, improved erections.
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What is the appropriate dose of Uprima?
Uprima is supplied in 2mg and 3mg tablets individual should take Uprima at least 30 minutes prior to sexual intercourse. Uprima is most effective if individuals first consume a glass of water and then place the tablet under the tongue allowing the medication to dissolve. Most physicians recommend taking the 2mg tablets first and then increasing the dose to 3mg if necessary. Individuals should not consume more than 3mg of Uprima in any given eight hour period.
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Will I have spontaneous erections with Uprima?
Similar to Viagra, an individuals must have some sort of stimulation prior to achieving an erection, spontaneous erections are uncommon.
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What is the median time from dissolving Uprima under the tongue and the onset of an enhanced erection?
Uprima Clinical studies have shown:
34% of the erections occurred within 10 minutes of dissolving the Uprima tablet under the tongue.
66% of the erections occurred within 20 minutes of dissolving the Uprima tablet under the tongue.
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Will Uprima allow me to have an erection for hours?
Once an individual ejaculates his erection will return to the normal flaccid state. Uprima, however, can shorten the resolution phase or the time it takes to achieve another erection.
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What if Uprima does not produce the desired effects that I anticipated?
If Uprima does not produce the desired effects do not despair. Uprima is just one in many treatment options for erectile dysfunction.
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Does the use of Uprima offer any protection against sexually transmitted diseases?
No, the use of Uprima offers no protection against sexually transmitted diseases, including HIV. Patients should continue to use protective measures necessary to guard against these diseases.
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Should I use Uprima if I have not had sexual intercourse in a long time?
Sexual activity can cause a strain on the cardiovascular system. If you have not had any physical activity or if you have any pre-existing medical conditions you should consult with your local physician prior to using Uprima.
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What types of results did Uprima produce during clinical trials?
Rome -- Men with erectile dysfunction (ED) who responded to Uprima (apomorphine hydrochloride SL) showed consistently high rates of success over 18 months, according to data presented at the 4th Congress of the European Society for Sexual and Impotence Research (ESSIR). Across the entire study period, an average of 92 percent of attempts resulted in an erection firm enough for intercourse among patients taking Uprima2 mg(1). Efficacy was measured as the percentage of attempts resulting in an erection firm enough for intercourse with Uprima, according to patient and partner diary assessments. Both patient and partner evaluations confirmed the success rate.
The findings provide important evidence of the long-term efficacy of Uprima, the first centrally acting oral therapy to be approved for the first- line treatment of erectile dysfunction.
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What are the precautions/warnings concerning Uprima?
Individuals who have the following medical conditions should not take Uprima:
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Cardiovascular complications i.e. heart attack, congestive heart failure, unstable angina (chest pain), uncontrolled hypertension or hypotension, history of postural hypotension, stroke,
Compromised renal or hepatic function
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Abnormally formed penis i.e. angulation, cavernosal fibrosis, Pyronie's disease
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Uprima should not be used in men where sexual activity is inadvisable
Medications:
Patients taking certain medications to treat medical conditions i.e. nitrate medications, certain hypertensive medications, centrally acting dopamine agonist or antagonists.
Note: Nitrates are found in many prescription medications used to treat angina (chest pain secondary to heart disease). Nitrates are also found in recreational drugs.
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Nitroglycerin ( skin patches or pastes, sprays, ointments and tablets that are used orally)
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Isosorbide mononitrate and isosorbide dinitrate (tablets that are swallowed, chewed or dissolved in the mouth)
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Nitrates are found in recreational drugs i.e. amyl nitrate or nitrate ("poppers"). Individuals who are not sure if any of their medications contain nitrates should consult with their healthcare professional prior to using Uprima.
Men who are taking medicines that contain nitrates (Nitroglycerin) of any kind must never use Uprima. Patients should not take Uprima even if you only take nitroglycerin medication occasionally.
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May I consume alcohol while taking Uprima?
Consuming alcohol while taking Uprima is not recommended. The combination may increase the possibility of hypotension (low blood pressure). In addition, alcohol may reduce sexual performance.
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What happens if there is no sexual stimulation following the ingestion of Uprima?
Uprima is naturally eliminated from your body in a few hours.
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Can Uprima be combined with other treatments for impotence?
The use of such combined treatments is not recommended, since no studies have been done to access Uprima's safety and effectiveness.
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Are there any populations were Uprima has not been clinically tested?
Yes, there are several medical conditions were the effectiveness of Uprima have not been clinically tested i.e. patients with spinal cord injuries, multiple sclerosis, status post pelvic surgery including radical prostatectomy.
Conclusions About Uprima
Uprima remains unique from the other erection dysfunction treatment medications in that the Uprima is placed under the tongue allowing the erectile dysfunction drug to bypass the gastrointestinal tract. This delivery method allows Uprima to be one of the fastest acting erection enhancement drugs.
Unlike other erectile dysfunction treatments, Uprima, exerts its action as a dopamine receptor agonist that works in the brain to improve diminished erectile function by enhancing the natural process or signal to the penis following sexual stimulation.
Uprima is unique in that it works through the central nervous system, producing a series of events that enhances erections quickly. The novel mode of enhancing erections allows Uprima to be one of the fastest acting erectile dysfunction treatments available on the market.
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